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ea0081p583 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Waist-to-height ratio is a predictor of weight loss with Gelesis200 treatment for people with overweight or obesity having prediabetes or type 2 diabetes in the LIGHT-UP study

Luzi Livio , Greenway Frank , Miller Sam , Matejkova Erika , McLean Barry , Zmuda Witold , Bogdanski Pawel , Arciszewska Malgorzata , Sjodin Anders , Salz Judith , Bochenek-Mularczyk Anna , Lewy-Alterbaum Lorena , Butcher Michael , Paragh Gyorgy , Davis Yvonne , Wilding John , Golub Howard , Leider Harry , Zohar Yishai , Sannino Alessandro , Calderon Henry , Heshmati Hassan

Introduction: Methods to predict clinically meaningful weight loss can help tailor treatment for people with overweight or obesity. LIGHT-UP (NCT03058029), is a multicenter, double-blind, randomized, placebo-controlled study over 25 weeks including 254 people with prediabetes or type 2 diabetes (127 each in the Gelesis200 and placebo arms) with a body mass index between 27 and 40 kg/m2, which demonstrated that Gelesis200 offers a compelling new potential approach in...

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ea0063gp139 | Obesity | ECE2019

Prediction of clinically significant weight loss with Gelesis100 in the GLOW study as early as 8 weeks post-treatment

Luzi Livio , Raben Anne , Astrup Arne , Matejkova Erika , Svacina Stepan , Gnessi Lucio , Navas-Carretero Santiago , Martinez J Alfredo , Greenway Frank , Aronne Louis , Apovian Caroline , Kaplan Lee , Hill James , Fujioka Ken , Still Christopher , Sannino Alessandro , Saponaro Cosimo , Calderon Henry , Urban Lorien , Chiquette Elaine , Leider Harry , Ron Eyal , Zohar Yishai , Heshmati Hassan

Introduction: Identification of early responders is widely used in pharmacotherapy for weight loss to minimize unnecessary exposure to risks and unnecessary expenses. Gelesis Loss Of Weight (GLOW; NCT02307279), a multicenter, double-blind, placebo-controlled pivotal study, demonstrated that Gelesis100 offers a compelling new potential approach in the management of overweight and obesity.Objective: A post-hoc area under the curve (AUC) for the receiver op...

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Endocrine Abstracts

Waist-to-height ratio is a predictor of weight loss with Gelesis200 treatment for people with overweight or obesity having prediabetes or type 2 diabetes in the LIGHT-UP study

Prediction of clinically significant weight loss with Gelesis100 in the GLOW study as early as 8 weeks post-treatment

BiosciAbstracts